Manuscripts

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2016
NCBI Manuscript

Fosfomycin: A First-Line Oral Therapy for Acute Uncomplicated Cystitis.

Zhanel GG, Walkty AJ, Karlowsky JA.

Can J Infect Dis Med Microbiol. 2016;2016:2082693. doi: 10.1155/2016/2082693. Epub 2016 May 10. Review. PMID: 27366158

 

NCBI Manuscript

Invasive Streptococcus pneumoniae in Canada, 2011-2014: Characterization of new candidate 15-valent pneumococcal conjugate vaccine serotypes 22F and 33F.

Golden AR, Adam HJ, Zhanel GG; Canadian Antimicrobial Resistance Alliance (CARA).

Vaccine. 2016 May 17;34(23):2527-30. doi: 10.1016/j.vaccine.2016.03.058. Epub 2016 Apr 13. PMID: 27085174

 

NCBI Manuscript

Review of Eravacycline, a Novel Fluorocycline Antibacterial Agent.

Zhanel GG, Cheung D, Adam H, Zelenitsky S, Golden A, Schweizer F, Gorityala B, Lagacé-Wiens PR, Walkty A, Gin AS, Hoban DJ, Karlowsky JA.

Drugs. 2016 Apr;76(5):567-88. doi: 10.1007/s40265-016-0545-8. Review. PMID: 26863149

 

2015
NCBI Manuscript

Fidaxomicin: A novel agent for the treatment of Clostridium difficile infection.

Zhanel GG, Walkty AJ, Karlowsky JA.

Can J Infect Dis Med Microbiol. 2015 Nov-Dec;26(6):305-12. Review. PMID: 26744587

 

NCBI Manuscript

Telavancin: Mechanisms of Action, In Vitro Activity, and Mechanisms of Resistance.

Karlowsky JA, Nichol K, Zhanel GG.

Clin Infect Dis. 2015 Sep 15;61 Suppl 2:S58-68. doi: 10.1093/cid/civ534. PMID: 26316559

 

NCBI Manuscript

Characterization of MDR and XDR Streptococcus pneumoniae in Canada, 2007-13.

Golden AR, Rosenthal M, Fultz B, Nichol KA, Adam HJ, Gilmour MW, Baxter MR, Hoban DJ, Karlowsky JA, Zhanel GG.

J Antimicrob Chemother. 2015 Aug;70(8):2199-202. doi: 10.1093/jac/dkv107. Epub 2015 Apr 28. PMID: 25921512

 

NCBI Manuscript

Epidemiology of vancomycin-resistant enterococci in Canadian hospitals (CANWARD study, 2007 to 2013).

Simner PJ, Adam H, Baxter M, McCracken M, Golding G, Karlowsky JA, Nichol K, Lagacé-Wiens P, Gilmour MW; Canadian Antimicrobial Resistance Alliance (CARA), Hoban DJ, Zhanel GG.

Antimicrob Agents Chemother. 2015 Jul;59(7):4315-7. doi: 10.1128/AAC.00384-15. Epub 2015 Apr 20. PMID: 25896693

 

NCBI Manuscript

In vitro activity of ceftazidime-avibactam against 338 molecularly characterized gentamicin-nonsusceptible Gram-negative clinical isolates obtained from patients in Canadian hospitals.

Denisuik AJ, Karlowsky JA, Denisuik T, Nichols WW, Keating TA, Adam HJ, Baxter M, Walkty A,Zhanel GG.

Antimicrob Agents Chemother. 2015 Jun;59(6):3623-6. doi: 10.1128/AAC.00364-15. Epub 2015 Mar 30. PMID: 25824208

 

NCBI Manuscript

Assessment of multidrug resistance, clonality and virulence in non-PCV-13 Streptococcus pneumoniae serotypes in Canada, 2011-13.

Golden AR, Adam HJ, Gilmour MW, Baxter MR, Martin I, Nichol KA, Demczuk WH, Hoban DJ,Zhanel GG.

J Antimicrob Chemother. 2015 Jul;70(7):1960-4. doi: 10.1093/jac/dkv061. Epub 2015 Mar 11. PMID: 25761605

 

NCBI Manuscript

Tedizolid: a novel oxazolidinone with potent activity against multidrug-resistant gram-positive pathogens.

Zhanel GG, Love R, Adam H, Golden A, Zelenitsky S, Schweizer F, Gorityala B, Lagacé-Wiens PR, Rubinstein E, Walkty A, Gin AS, Gilmour M, Hoban DJ, Lynch JP 3rd, Karlowsky JA.

Drugs. 2015 Feb;75(3):253-70. doi: 10.1007/s40265-015-0352-7. PMID: 25673021

 

2014
NCBI Manuscript

In vitro activity of plazomicin against 5,015 gram-negative and gram-positive clinical isolates obtained from patients in canadian hospitals as part of the CANWARD study, 2011-2012.

Walkty A, Adam H, Baxter M, Denisuik A, Lagacé-Wiens P, Karlowsky JA, Hoban DJ, Zhanel GG.

Antimicrob Agents Chemother. 2014 May;58(5):2554-63. doi: 10.1128/AAC.02744-13. Epub 2014 Feb 18. PMID: 24550325

 

NCBI Manuscript

In vitro activity of oritavancin against Gram-positive pathogens isolated in Canadian hospital laboratories from 2011 to 2013.

Karlowsky JA, Walkty AJ, Baxter MR, Adam HJ, Zhanel GG.

Diagn Microbiol Infect Dis. 2014 Sep 16. pii: S0732-8893(14)00365-4. doi: 10.1016/j.diagmicrobio.2014.09.003. [Epub ahead of print] PMID: 25294303

 

NCBI Manuscript

Pharmacodynamic activity of ertapenem versus genotypically characterized extended-spectrum β-lactamase (ESBL)-, KPC- or NDM-producing Escherichia coli with reduced susceptibility or resistance to ertapenem using an in vitro model.

Zhanel GG, Denisuik A, Vashisht S, Yachison C, Adam HJ, Hoban DJ.

J Antimicrob Chemother. 2014 Sep;69(9):2448-52. doi: 10.1093/jac/dku149. Epub 2014 May 14. PMID: 24827891

 

NCBI Manuscript

Ceftolozane/tazobactam: a novel cephalosporin/β-lactamase inhibitor combination with activity against multidrug-resistant gram-negative bacilli.

Zhanel GG, Chung P, Adam H, Zelenitsky S, Denisuik A, Schweizer F, Lagacé-Wiens PR, Rubinstein E, Gin AS, Walkty A, Hoban DJ, Lynch JP 3rd, Karlowsky JA.

Drugs. 2014 Jan;74(1):31-51. doi: 10.1007/s40265-013-0168-2. PMID: 24352909

 

NCBI Manuscript

In Vitro activity of fosfomycin against Escherichia coli isolated from patients with urinary tract infections in Canada as part of the CANWARD surveillance study.

Karlowsky JA, Denisuik AJ, Lagacé-Wiens PR, Adam HJ, Baxter MR, Hoban DJ, Zhanel GG.

Antimicrob Agents Chemother. 2014;58(2):1252-6. doi: 10.1128/AAC.02399-13. Epub 2013 Dec 9. PMID: 24323476

 

2013
NCBI Manuscript

Introduction to the CANWARD study (2007–11).

Hoban DJ, Zhanel GG.

J Antimicrob Chemother. 2013 May;68 Suppl 1:i3-5. PMID: 23720829

 

NCBI Manuscript

Antimicrobial susceptibility of 22746 pathogens from Canadian hospitals: results of the CANWARD 2007-11 study.

Zhanel GG, Adam HJ, Baxter MR, Fuller J, Nichol KA, Denisuik AJ, Lagacé-Wiens PR, Walkty A, Karlowsky JA, Schweizer F, Hoban DJ; Canadian Antimicrobial Resistance Alliance.

J Antimicrob Chemother. 2013 May;68 Suppl 1:i7-22. PMID: 23587781 [PubMed - in process]

 

NCBI Manuscript

Integrating pharmacokinetics, pharmacodynamics and MIC distributions to assess changing antimicrobial activity against clinical isolates of Pseudomonas aeruginosa causing infections in Canadian hospitals (CANWARD).

Zelenitsky SA, Rubinstein E, Ariano RE, Zhanel GG; Canadian Antimicrobial Resistance Alliance.

J Antimicrob Chemother. 2013 May;68 Suppl 1:i6-72. PMID: 23587780

 

NCBI Manuscript

Molecular epidemiology of extended-spectrum β-lactamase-, AmpC β-lactamase- and carbapenemase-producing Escherichia coli and Klebsiella pneumoniae isolated from Canadian hospitals over a 5 year period: CANWARD 2007-11.

Zelenitsky SA, Rubinstein E, Ariano RE, Zhanel GG; Canadian Antimicrobial Resistance Alliance.

J Antimicrob Chemother. 2013 May;68 Suppl 1:i6-72. PMID: 23587779

 

NCBI Manuscript

Changing epidemiology of methicillin-resistant Staphylococcus aureus in Canada.

Nichol KA, Adam HJ, Roscoe DL, Golding GR, Lagacé-Wiens PR, Hoban DJ, Zhanel GG; Canadian Antimicrobial Resistance Alliance.

J Antimicrob Chemother. 2013 May;68 Suppl 1:i47-55. PMID: 23587778

 

NCBI Manuscript

Changes in fluoroquinolone resistance over 5 years (CANWARD 2007-11) in bacterial pathogens isolated in Canadian hospitals.

Karlowsky JA, Adam HJ, Desjardins M, Lagacé-Wiens PR, Hoban DJ, Zhanel GG; Canadian Antimicrobial Resistance Alliance.

J Antimicrob Chemother. 2013 May;68 Suppl 1:i39-46. PMID: 23587777

 

NCBI Manuscript

Comparison of pathogens and their antimicrobial resistance patterns in paediatric, adult, and elderly patients in Canadian hospitals.

Adam HJ, Baxter MR, Davidson RJ, Rubinstein E, Fanella S, Karlowsky JA, Lagacé-Wiens PR, Hoban DJ, Zhanel GG; Canadian Antimicrobial Resistance Alliance (CARA).

J Antimicrob Chemother. 2013 May;68 Suppl 1:i31-7. PMID: 23587776

 

NCBI Manuscript

Trends in antibiotic resistance over time among pathogens from Canadian hospitals: results of the CANWARD study 2007-11.

Lagacé-Wiens PR, Adam HJ, Low DE, Blondeau JM, Baxter MR, Denisuik AJ, Nichol KA, Walkty A, Karlowsky JA, Mulvey MR, Hoban DJ, Zhanel GG; Canadian Antimicrobial Resistance Alliance.

J Antimicrob Chemother. 2013 May;68 Suppl 1:i23-9. PMID: 23587775

 

NCBI Manuscript

Ceftazidime-avibactam: a novel cephalosporin/β-lactamase inhibitor combination.

Zhanel GG, Lawson CD, Adam H, Schweizer F, Zelenitsky S, Lagacé-Wiens PR, Denisuik A, Rubinstein E, Gin AS, Hoban DJ, Lynch JP 3rd, Karlowsky JA.

Drugs. 2013 Feb;73(2):159-77. PMID: 23371303

 

2012
NCBI Manuscript

Antimicrobial susceptibility of Pseudomonas aeruginosa isolates obtained from patients in Canadian hospitals: CANWARD 2008-2011.

Walkty A, Baxter M, Adam H, Karlowsky JA, Lagacé-Wiens P, Hoban DJ, Zhanel GG.

Diagn Microbiol Infect Dis. 2012 Aug;73(4):361-4. Epub 2012 Jun 12. PMID: 22694789

 

NCBI Manuscript

Prevalence of antimicrobial resistance among clinical isolates of Bacteroides fragilis group in Canada in 2010-2011: CANWARD surveillance study.

Karlowsky JA, Walkty AJ, Adam HJ, Baxter MR, Hoban DJ, Zhanel GG.

Antimicrob Agents Chemother. 2012 Mar;56(3):1247-52. Epub 2011 Dec 27. PMID: 22203594 [PubMed - indexed for MEDLINE]

 

NCBI Manuscript

Investigating the antimicrobial peptide 'window of activity' using cationic lipopeptides with hydrocarbon and fluorinated tails.

Findlay B, Zhanel GG, Schweizer F.

Int J Antimicrob Agents. 2012 Jul;40(1):36-42. PMID: 22578748

 

NCBI Manuscript

Oritavancin: mechanism of action.

Zhanel GG, Schweizer F, Karlowsky JA.

Clin Infect Dis. 2012 Apr;54 Suppl 3:S214-9. PMID: 22431851

 

NCBI Manuscript

Comparison of the next-generation aminoglycoside plazomicin to gentamicin, tobramycin and amikacin.

Zhanel GG, Lawson CD, Zelenitsky S, Findlay B, Schweizer F, Adam H, Walkty A, Rubinstein E, Gin AS, Hoban DJ, Lynch JP, Karlowsky JA.

Expert Rev Anti Infect Ther. 2012 Apr;10(4):459-73. PMID: 22512755

 

NCBI Manuscript

 

NCBI Manuscript

Baseline epidemiology of Streptococcus pneumoniae serotypes in Canada prior to the introduction of the 13-valent pneumococcal vaccine.

Adam HJ, Karlowsky JA, Nichol KA, Gilmour MW, Hoban DJ, Embree J, Zhanel GG.

JMicrob Drug Resist. 2012 Apr;18(2):176-82. PMID: 22204595

 

2011
NCBI Manuscript

Fluoroquinolone resistance in Escherichia coli isolated from patients attending Canadian hospitals is associated with the ST131 clone.

Simner PJ, Hoban DJ, Lagacé-Wiens PR, Zhanel GG, Karlowsky JA.

Diagn Microbiol Infect Dis. 2011 Nov;71(3):323-4. Epub 2011 Sep 1. No abstract available. PMID: 21889284 [PubMed - indexed for MEDLINE]

 

NCBI Manuscript

Antimicrobial resistance in urinary tract pathogens in Canada from 2007 to 2009: CANWARD surveillance study.

Karlowsky JA, Lagacé-Wiens PR, Simner PJ, DeCorby MR, Adam HJ, Walkty A, Hoban DJ, Zhanel GG.

Antimicrob Agents Chemother. 2011 Jul;55(7):3169-75. Epub 2011 May 2. PMID: 21537027[PubMed - indexed for MEDLINE]

 

NCBI Manuscript

In vitro activity of ceftazidime combined with NXL104 versus Pseudomonas aeruginosa isolates obtained from patients in Canadian hospitals (CANWARD 2009 study).

Walkty A, DeCorby M, Lagacé-Wiens PR, Karlowsky JA, Hoban DJ, Zhanel GG.

Antimicrob Agents Chemother. 2011 Jun;55(6):2992-4. Epub 2011 Mar 21. PMID: 21422208 [PubMed - indexed for MEDLINE]

 

NCBI Manuscript

Activity of NXL104 in combination with beta-lactams against genetically characterized Escherichia coli and Klebsiella pneumoniae isolates producing class A extended-spectrum beta-lactamases and class C beta-lactamases.

Lagacé-Wiens PR, Tailor F, Simner P, DeCorby M, Karlowsky JA, Walkty A, Hoban DJ, Zhanel GG.

Antimicrob Agents Chemother. 2011 May;55(5):2434-7. Epub 2011 Feb 28. PMID: 21357295 [PubMed - indexed for MEDLINE]

 

NCBI Manuscript

In vitro activity of ceftobiprole against frequently encountered aerobic and facultative Gram-positive and Gram-negative bacterial pathogens: results of the CANWARD 2007-2009 study.

Walkty A, Adam HJ, Laverdière M, Karlowsky JA, Hoban DJ, Zhanel GG; the Canadian Antimicrobial Resistance Alliance (CARA).

Diagn Microbiol Infect Dis. 2011 Mar;69(3):348-355. PMID: 21353964 [PubMed - as supplied by publisher]

 

NCBI Manuscript

In vitro activity of dalbavancin and telavancin against staphylococci and streptococci isolated from patients in Canadian hospitals: results of the CANWARD 2007-2009 study.

Karlowsky JA, Adam HJ, Poutanen SM, Hoban DJ, Zhanel GG; The Canadian Antimicrobial Resistance Alliance (CARA).

Diagn Microbiol Infect Dis. 2011 Mar;69(3):342-347. PMID: 21353963 [PubMed - as supplied by publisher]

 

NCBI Manuscript

Characterization of Acinetobacter baumannii and meropenem-resistant Pseudomonas aeruginosa in Canada: results of the CANWARD 2007-2009 study.

McCracken M, Mataseje LF, Loo V, Walkty A, Adam HJ, Hoban DJ, Zhanel GG, Mulvey MR; the Canadian Antimicrobial Resistance Alliance (CARA).

Diagn Microbiol Infect Dis. 2011 Mar;69(3):335-341. PMID: 21353962 [PubMed - as supplied by publisher]

 

NCBI Manuscript

Prevalence and characterization of extended-spectrum β-lactamase- and AmpC β-lactamase-producing Escherichia coli: results of the CANWARD 2007-2009 study.

Simner PJ, Zhanel GG, Pitout J, Tailor F, McCracken M, Mulvey MR, Lagacé-Wiens PR, Adam HJ, Hoban DJ; the Canadian Antimicrobial Resistance Alliance (CARA).

Diagn Microbiol Infect Dis. 2011 Mar;69(3):326-334. PMID: 21353961[PubMed - as supplied by publisher]

 

NCBI Manuscript

Comparison of community-associated and health care-associated methicillin-resistant Staphylococcus aureus in Canada: results of the CANWARD 2007-2009 study.

Nichol KA, Adam HJ, Hussain Z, Mulvey MR, McCracken M, Mataseje LF, Thompson K, Kost S, Lagacé-Wiens PR, Hoban DJ, Zhanel GG; The Canadian Antimicrobial Resistance Alliance (CARA).

Diagn Microbiol Infect Dis. 2011 Mar;69(3):320-325. PMID: 21353960 [PubMed - as supplied by publisher]

 

NCBI Manuscript

Analysis of 3789 in- and outpatient Escherichia coli isolates from across Canada-results of the CANWARD 2007-2009 study.

Lagacé-Wiens PR, Simner PJ, Forward KR, Tailor F, Adam HJ, Decorby M, Karlowsky J, Hoban DJ, Zhanel GG; The Canadian Antimicrobial Resistance Alliance (CARA).

Diagn Microbiol Infect Dis. 2011 Mar;69(3):314-319. PMID: 21353959 [PubMed - as supplied by publisher]

 

NCBI Manuscript

Prevalence of antimicrobial resistant pathogens from blood cultures from Canadian hospitals: results of the CANWARD 2007-2009 study.

Adam HJ, Decorby M, Rennie R, Karlowsky JA, Hoban DJ, Zhanel GG; The Canadian Antimicrobial Resistance Alliance (CARA).

Diagn Microbiol Infect Dis. 2011 Mar;69(3):307-313. PMID: 21353958 [PubMed - as supplied by publisher]

 

NCBI Manuscript

Antimicrobial susceptibility of 15,644 pathogens from Canadian hospitals: results of the CANWARD 2007-2009 study.

Zhanel GG, Adam HJ, Low DE, Blondeau J, Decorby M, Karlowsky JA, Weshnoweski B, Vashisht R, Wierzbowski A, Hoban DJ; The Canadian Antimicrobial Resistance Alliance (CARA).

Diagn Microbiol Infect Dis. 2011 Mar;69(3):291-306. PMID: 21353957 [PubMed - as supplied by publisher]

 

NCBI Manuscript

Introduction to the CANWARD Study (2007-2009).

Hoban DJ, Zhanel GG.

Diagn Microbiol Infect Dis. 2011 Mar;69(3):289-90. No abstract available. PMID: 21353956 [PubMed - in process]

 

2010
NCBI Manuscript

Prevalence of antimicrobial-resistant pathogens in Canadian hospitals: results of the Canadian Ward Surveillance Study (CANWARD 2008).

Zhanel GG, DeCorby M, Adam H, Mulvey MR, McCracken M, Lagacé-Wiens P, Nichol KA, Wierzbowski A, Baudry PJ, Tailor F, Karlowsky JA, Walkty A, Schweizer F, Johnson J; Canadian Antimicrobial Resistance Alliance, Hoban DJ.

ntimicrob Agents Chemother. 2010 Nov;54(11):4684-93. Epub 2010 Aug 30.PMID: 20805395 [PubMed - in process]

 

NCBI Manuscript

Pharmacodynamics of empirical antibiotic monotherapies for an intensive care unit (ICU) population based on Canadian surveillance data.

Zelenitsky SA, Ariano RE, Zhanel GG.

J Antimicrob Chemother. 2010 Oct 5. [Epub ahead of print] PMID: 20926397 [PubMed - as supplied by publisher]

 

NCBI Manuscript

Streptococcus pneumoniae: epidemiology and risk factors, evolution of antimicrobial resistance, and impact of vaccines.

Lynch JP 3rd, Zhanel GG.

Curr Opin Pulm Med. 2010 May;16(3):217-25.PMID: 20375783 [PubMed - in process]

 

NCBI Manuscript

New lipoglycopeptides: a comparative review of dalbavancin, oritavancin and telavancin.

Zhanel GG, Calic D, Schweizer F, Zelenitsky S, Adam H, Lagacé-Wiens PR, Rubinstein E, Gin AS, Hoban DJ, Karlowsky JA.

Drugs. 2010 May 7;70(7):859-86. doi: 10.2165/11534440-000000000-00000.PMID: 20426497 [PubMed - in process]